Fall Semester Course: Neuroinfectious Diseases

SYLLABIS: Neuroinfectious Diseases: Important Concepts and Classic Literature

Course Master: Robyn S. Klein, M.D., Ph.D.


September 12– Routes for pathogens and immune cells: Blood-, CSF-brain barriers, CNS lymphatic and Approach to the Patient with a Suspected Neuroinfectious Disease/Robyn S. Klein, MD, PhD

September 19– Management of Cryptococcal Meningitis/David B. Clifford, MD

September 26– Acute Meningitis/Robyn S. Klein, MD, PhD

October 3– NeuroHIV overview/David B. Clifford, MD

October 10– Toxoplasma encephalitis/David B. Clifford, MD

October 17– Chronic meningitis and Brain Abscesses/Robyn S. Klein, MD, PhD

October 24– Encephalitis/Robyn S. Klein, MD, PhD

October 31– Parenchymal Infections/Parasites

November 7– CNS TB and HIV/David B. Clifford, MD

November 21– HIV associated neurocognitive disorders (HAND)/Beau Ances, MD, PhD

November 28– Spirochaetal Infections/David B. Clifford, MD, PhD

December 5– HTLV-1 Myelopathy/David B. Clifford, MD

December 12– Post-infectious/Paraneoplastic CNS Syndromes/ Beau Ances, MD, PhD

December 19– Sarcoidosis/David B. Clifford, MD and Beau Ances, MD, PhD

NeuroID Course Reading List

  1. Booss, John and Tselis, Alex C., “A History of viral Infections of the Central Nervous System: Foundations, Milestones and Patterns.” Handbook of Clinical Neurology, Vol. 123(3rd series); Neurovirology 2014, 3-44.
  2. Koedel, Uwe; Klein, Matthias; and Pfister, Hans-Walter. “New Understandings on the Pathophysiology of Bacterial Meningitis.” Current Opinion in Infectious Diseases 2010, 23:217-223.
  3. Edberg, M; Furebring, M; Sjolin, J; and Enblad, P. “Neurointensive Care of Patients with Severe Community-Acquired Meningitis.” Acta Anaesthesiol Scand 2011; 55:732-739.
  4. Van de Bee, D. “Corticosteroids for Acute Adult Bacterial Meningitis.” Medecine et maladies infectieuses 2009; 39:531.538.
  5. Figaji, Anthony A and Fieggen, A. Graham. “The Neurosurgical and Acute Care Management of Tuberculous Meningitis: Evidence and Current Practice.” Tuberculosis 2010; 90:393-400.
  6. Vinnard, Christopher and Macgregor, Rob Roy. “Tuberculous Meningitis in HIV-Infected Individuals.” Curr HIV/AIDS Rep 2009; 6(3):139-145.
  7. Helbok, Raimund; Broessner, Gregor; Pfausler, Bettina; and Schmutzhard, Erich. “Chronic Meningitis.” J Neurol 2009; 256:168-175.
  8. Panackal, Anil A and Williamson, Peter R. “Fungal Infections of the Central Nervous System.” Continuum (Minneap Minn) 2015; 21(6):1662-1678.
  9. Bradshaw, Michael J and Venkatesan, Arun. “Herpes Simplex Virus-1 Encephalitis in Adults: Pathophysiology, Diagnosis, and Management.” Neurotherapeutics 2016; 13:493-508.
  10. Bogovic, Petra; Lotric-Furlan, Stanka; and Strle, Franc. “What Tick-Borne Encephalitis May Look Like: Clinical Signs and Symptoms.” Travel Medicine and Infectious Disease 2010; 8:246-250.
  11. Davis, Larry E; Beckham, J. David; and Tyler, Kenneth L. “North American Encephalitic Arboviruses.” Neurol Clin 2008; 26(3):727-ix.
  12. Tsiodras, S; Kelesidis, I; Kelesidis, T; Stamboulis, E; and Giamarellou, H. “Central Nervous Systems Manifestations of Mycoplasma PneumoniaeJournal of Infection 2005; 51:343-354.
  13. Steiner, Israel; Kennedy Peter GE; and Pachner, Andrew R. “The Neurotropic Herpes Viruses: Herpes Simplex and Varicella-Zoster.” Lancet Neurol 2007; 6:1015-1028.
  14. Koeller, Kelly K and Shih, Robert Y. “Viral and Prion Infections of the Central Nervous System: Radiologic-Pathologic Correlation.” Radiographics 2017; 37:199-233.
  15. Sathiamoorthi, Saraniya and Smith, Wendy M. “The Eye and Tick-Borne Disease in the United States.” Curr Opin Ophthalmol 2016; 27:530-537.
  16. Marra, Christina M. “Neurosyphilis.” Continuum (Minneap Minn) 2015; 21(6):1714-1728.
  17. Gelman, Benjamin B. “Neuropathology of HAND with Suppressive Antiretroviral Therapy: Encephalitis and Neurodegeneration Reconsidered.” Curr HIV/AIDS Rep 2015; 12:272-279.
  18. Mitoma, Hiroshi; Adhikari, Keya; Aeschlimann, Daniel; Chattopadhyay, Partha; Hadjivassiliou, Marios; Hampe, Christiane S; Honnorat, Jerome; Joubert, Bastien; Kakei, Shinji; Lee, Jongho; Manto, Mario; Matsunaga, Akiko; Mizusawa, Hidehiro; Nanri, Kazunori; Shanmugarajah, Priya; Yoneda, Makoto; and Yuki, Nobuhiro. “Consensus Paper: Neuroimmune Mechanisms of Cerebellar Ataxias.” Cerebellum 2016; 15:213-232.
  19. Daep, Carlo Amorin; Munoz-Jordan, Jorge L; and Eugenin, Eliseo Alberto. “Flaviviruses, an Expanding Threat in Public Health: Focus on Dengue, West Nile, and Japanese Encephalitis Virus.” J Neurovirol 2014; 20(6):539-560.
  20. Kivity, Shaye; Agmon-Levin, Nancy; Zandman-Goddard, Gisele; Chapman, Joab; and Shoenfeld, Yehuda. “Neuropsychiatric Lupus: A Mosaic of Clinical Presentations.” BMC Medicine 2015; 13:43.
  21. Mullins, GM; Elamin, M; Saidha, S; Ali, E; Jennings, L; Counihan, TJ; and Hennessy M. “Acute Aseptic Meningitis and Diffuse Myelitis as the Presenting Features of Neurological Behcet Disease.” Journal of Clinical Neuroscience 2009; 16:1702-1704.
  22. Hinkle, Clayton D; Porter, James N; Waldron, Eric J; Klein, Hannah; Tranel, Daniel; and Heffelfinger, Amy. “Neuropsychological Characterization of Three Adolescent Females with Anti-NMDA Receptor Encephalitis in the Acute, Post-Acute, and Chronic Phases: An Inter-Institutional Case Series.” The Clinical Neuropsychologist 2017; 31(1):268-288.
  23. Loughan, Ashlee R; Allen, Aislyn; Perna, Robert; and Malkin, Mark G. “Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Review and Neuropsychological Case Study.” The Clinical Neuropsychologist 2016; 30(1):150-163.
  24. Kumar, V. Anil; Augustine, Deepthi; Panikar, Dilip; Nandakumar, Aswathy; Dinesh, Kavitha R; Karim, Shamsul; and Philip, Rosamma. “Nocardia farcinica Brain Abscess: Epidemiology, Pathophysiology, and Literature Review.” Surgical Infections 2014; 15(5):640-646.
  25. Brouwer, MC and Van De Beek, D. “Management of Bacterial Central Nervous System Infections.” Handbook of Clinical Neurology 2017; 140(3rd series):349-364.
  26. Saez-Llorens, Xavier and Nieto-Guevara, Javier. “Brain Abscess.” Handbook of Clinical Neurology 2013; 112(3rd Series):1127-1134.